Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology
نویسندگان
چکیده
Lab Chip This journal is © The Royal Society of Chemistry 2014 Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA. E-mail: [email protected]; Fax: +1 (913) 945 6373; Tel: +1 (913) 945 6327 Department of Chemistry, Ralph N Adams Institute for Bioanalytical Chemistry, and Bioengineering Graduate Program, University of Kansas, Lawrence, KS 66045, USA. E-mail: [email protected]; Fax: +1 (785) 864 5396; Tel: +1 (785) 864 8105 c University of Kansas Cancer Center, Kansas City, KS 66160, USA † Author contributions: M. H., Y. Z. and A. K. G. conceived research; M. H. and Y. Z. designed and fabricated the devices; M. H., Y. Z., J. C., and M. R. performed the research; M. H., Y. Z., and A. K. G. analyzed the data; M. H., Y. Z., and A. K. G. wrote the manuscript. ‡ Electronic supplementary information (ESI) available. See DOI: 10.1039/ c4lc00662c § Current address: Department of Biological and Agricultural Engineering, Kansas State University, Olathe, KS 66061. Cite this: Lab Chip, 2014, 14, 3773
منابع مشابه
Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology† †Author contributions: M. H., Y. Z. and A. K. G. conceived research; M. H. and Y. Z. designed and fabricated the devices; M. H., Y. Z., J. C., and M. R. performed the research; M. H., Y. Z., and A. K. G. analyzed the data; M. H., Y. Z., and A. K. G. wrote the manuscript. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c4lc00662c Click here for additional data file.
Developing blood-based tests is appealing for non-invasive disease diagnosis, especially when biopsy is difficult, costly, and sometimes not even an option. Tumor-derived exosomes have attracted increasing interest in non-invasive cancer diagnosis and monitoring of treatment response. However, the biology and clinical value of exosomes remains largely unknown due in part to current technical ch...
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